GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs142039564 | 1 | rs142039564 | chr1:119056258 | WARS2 | chr1:119573841-119683295:- | -0.15 | -3.51 | 0.00046 | Response to efavirenz-containing treatment in HIV 1 infection (virologic failure) |
| BRCA | cis | rs10043228 | 1 | rs1422500 | chr5:115569312 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 4.5 | 7.45E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10461617 | 1 | rs1423620 | chr5:56100996 | C5orf35 | chr5:56205103-56213010:+ | 0.72 | 18.49 | 1.84E-66 | Type 2 diabetes |
| BRCA | cis | rs10461617 | 1 | rs1423621 | chr5:56101035 | C5orf35 | chr5:56205103-56213010:+ | 0.72 | 19.15 | 1.78E-70 | Type 2 diabetes |
| BRCA | cis | rs143000161 | 1 | rs143000161 | chr2:165710540 | SLC38A11 | chr2:165754812-165812035:- | 0.28 | 5.67 | 1.89E-8 | Heschl's gyrus morphology |
| BRCA | cis | rs7200543 | 1 | rs14347 | chr16:15133889 | C16orf63 | chr16:15959577-15982447:- | 0.14 | 3.9 | 0.000104 | Metabolic traits;Glycerophospholipid levels |
| BRCA | cis | rs965513 | 1 | rs1443438 | chr9:100550028 | NCBP1 | chr9:100395705-100436027:+ | -0.12 | -3.57 | 0.000368 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs965513 | 1 | rs1443438 | chr9:100550028 | TSTD2 | chr9:100362364-100395962:- | -0.1 | -3.68 | 0.000249 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| BRCA | cis | rs11750568 | 1 | rs1445845 | chr5:178507090 | ZNF354C | chr5:178487607-178507689:+ | -0.11 | -3.91 | 9.85E-5 | Height |
| BRCA | cis | rs11750568 | 1 | rs1445846 | chr5:178507069 | ZNF354C | chr5:178487607-178507689:+ | -0.12 | -4.24 | 2.48E-5 | Height |
| BRCA | cis | rs1668357 | 1 | rs1450849 | chr7:37992877 | EPDR1 | chr7:37960163-37991539:+ | -0.24 | -4.15 | 3.65E-5 | Myopia (pathological) |
| BRCA | cis | rs1451375 | 1 | rs1451374 | chr7:50622653 | FIGNL1 | chr7:50511834-50518088:- | -0.13 | -4.35 | 1.51E-5 | Malaria |
| BRCA | cis | rs1451375 | 1 | rs1451375 | chr7:50622712 | FIGNL1 | chr7:50511834-50518088:- | 0.12 | 3.92 | 9.24E-5 | Malaria |
| BRCA | cis | rs9475752 | 1 | rs1451707 | chr6:56801877 | BEND6 | chr6:56819773-56892138:+ | -0.36 | -9.72 | 1.91E-21 | Menarche (age at onset) |
| BRCA | cis | rs9475752 | 1 | rs1451707 | chr6:56801877 | KIAA1586 | chr6:56911384-56920021:+ | -0.19 | -3.72 | 0.000212 | Menarche (age at onset) |